Induction of murine CD5 expression by v‐H‐ ras
نویسندگان
چکیده
منابع مشابه
Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia.
In contrast to highly mutated follicular lymphomas and multiple myelomas, chronic lymphocytic leukemias (CLLs) frequently express VH genes in germline configuration. It is currently unclear whether this difference is related to the expression of CD5 or to the differentiation stage of the B cell when malignant transformation occurs. We have studied the VH sequence of 11 cases of CD5- B-CLL to ad...
متن کاملAnalysis of VH Gene Expression in CD5+ and CD5- B-Cell Chronic Lymphocytic Leukemia
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متن کاملAn NFAT-dependent enhancer is necessary for anti-IgM-mediated induction of murine CD5 expression in primary splenic B cells.
CD5 is a 67-kDa membrane glycoprotein the expression of which in murine splenic B cells is induced by surface IgM cross-linking. To analyze this induction, we transiently transfected primary splenic B cells with luciferase reporter constructs driven by various wild-type and mutated CD5 5'-flanking sequences. The transfected cells were subsequently cultured in medium with or without F(ab')2 anti...
متن کاملDevelopmentally regulated and strain-specific expression of murine VH gene families
We have devised a simple assay that provides an instantaneous representation of VH family usage in primary and peripheral lymphoid tissues. This assay lacks complex manipulations out of the animal and thus minimizes the risk of in vitro artifacts. We have used this assay to demonstrate a dramatic preference for utilization of the most JH-proximal VH segments in the newborn liver of BALB/c and C...
متن کاملDevelopmentally Regulated and Strain - Specific Expression of Murine Vh Gene Families by George D . Yancopoulos Barbara A
The genes that encode the antigen-binding portions (variable regions) of mam-malian Ig heavy (H) and light (L) chains are assembled from multiple germline DNA elements (1). Precursor B (pre-B) lymphocytes in "primary" B cell differentiation organs (the fetal liver and adult marrow) assemble and express first H and subsequently L chain genes in an ordered process that culminates in the generatio...
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ژورنال
عنوان ژورنال: Immunology
سال: 1997
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.1997.00133.x